Synthesis of 1.alpha.,25-dihydroxyergocalciferol
AssigneeHoffmann-La Roche Inc.
InventorsEnrico G. Baggiolini, Andrew D. Batcho, Alfred Boris, Milan R. Uskokovic
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Abstract
The invention is directed to a process and intermediates for the preparation of 1.alpha.,25-dihydroxyergocalciferol as well as substantially pure and crystalline 1.alpha.,25-dihydroxyergocolciferol. The end-product 1.alpha.,25-dihydroxyergocalciferol is useful in the treatment of disease states which are characterized by insufficient amounts of 1.alpha.,25-dihydroxycholecalciferol.
Claims3
A process of the preparation of 1.alpha.,25-dihydroxyergocalciferol of the formula ##STR22## which comprises the steps of (a) reacting a compound of the formula ##STR23## wherein R.sub.1 is lower alkyl, aryl, or ar-lower alkyl, with a compound of the formula ##STR24## wherein R.sub.1 is as previously described to yield a corresponding compound of the formula ##STR25## wherein R.sub.1 as previously described, and (b) removing the protecting groups from a compound of formula IV, whereby there is obtained the compound of formula I.
Dependencies are inferred from the claim text.