Antibiotics produced by fermentation of a novel strain of Streptomyces hygroscopicus
AssigneeBristol-Myers Company
InventorsMinoru Hanada, Mitsuaki Tsunakawa, Koji Tomita, Hiroshi Tsukiura, Hiroshi Kawaguchi
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Abstract
Antibiotic Bu-2659 complex, containing components A, B, C, D and E, is produced by cultivation of Streptomyces hygroscopicus Strain No. J296-21, ATCC No. 39150.
Claims4
A process for the preparation of antibiotic Bu-2659 complex which comprises cultivating a strain of Streptomyces hygroscopicus ATCC No. 39150 under submerged aerobic conditions in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen at a temperature of from about 20.degree. C. to about 43.degree. C. until a substantial amount of Bu-2659 complex is produced and accumulated in the culture medium, and recovering the Bu-2659 complex from the culture medium.
The process of claim 3 wherein the cultivation is conducted at a temperature of from about 28.degree. C. to about 37.degree. C.
A biologically pure culture of the Bu-2659 complex-producing microorganism Streptomyces hygroscopicus Strain No. J296-21, ATCC No. 39150.
Dependencies are inferred from the claim text.