Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions
AssigneeBoehringer Mannheim GmbH
InventorsFritz Wiedemann, Wolfgang Kampe, Max Thiel, Gisbert Sponer, Egon Roesch, Karl Dietmann
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AssigneeBoehringer Mannheim GmbH
InventorsFritz Wiedemann, Wolfgang Kampe, Max Thiel, Gisbert Sponer, Egon Roesch, Karl Dietmann
Estimating the term…
Carbazolyl-(4)-oxypropanolamine compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkanoyl or aroyl; R.sub.2 is hydrogen, lower alkyl or arylalkyl; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen or lower alkyl, or when X is oxygen, R.sub.4 together with R.sub.5 can represent --CH.sub.2 --O--; X is a valency bond, --CH.sub.2 --, oxygen or sulfur; Ar is mono- or bicyclic aryl or pyridyl; R.sub.5 and R.sub.6 are individually selected from hydrogen, halogen, hydroxyl, lower alkyl, aminocarbonyl, lower alkoxy, aralkyloxy, lower alkylthio, lower alkylsulphinyl or lower alkylsulphonyl; R.sub.5 and R.sub.6 together can represent methylenedioxy; and the salts thereof with physiologically acceptable acids are outstandingly effective in the treatment and prophylaxis of circulatory and cardiac diseases, e.g., hypertension and angina pectoris.
Carbazolyl-(4)-oxypropanolamine compound of the formula ##STR9## wherein R.sub.1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl;
Dependencies are inferred from the claim text.