Stabilizing agents for live viruses for preparing vaccines, and stabilized vaccines containing said stabilizing agents
AssigneeInstitut Pasteur
InventorMichel Barme
Life of this patent
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Abstract
The stabilizing agent is constituted by a phosphate buffer solution (PBS) containing calcium and magnesium ions, which contains in addition lactose, sorbitol and at least one amino acid taken from the group which comprises histidine, alanine, valine, threonine, arginine, methionine, hydroxyproline, lysine, isoleucine, phenylalanine, serine, and preferably constituted by an association of histidine and alanine. The stabilized vaccine is constituted by a suspension of live attenuated viruses in the above stabilizing agent, and lyophilized. The invention also relates to the method for preparing such a stabilized vaccine, to the stabilized vaccines so-obtained and to their use for treating viral diseases in humans or animals.
Claims3
Stabilized vaccine containing attenuated live yellow fever virus
- said attenuated live yellow fever virus being essentially constituted by a suspension of live attenuated yellow fever virus in a stabilizing agent constituted by a phosphate buffer solution (PBS) containing calcium and magnesium ions, about 4% lactose, about 2% sorbitol and aboutn a 0.005M to 0.05M final concentration of at least one amino acid, said stabilized vaccine being lyophilised.
Dependencies are inferred from the claim text.