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US 4,500,462 AGranted
Unsaturated eicosanoic acids
AssigneeHoffmann-La Roche Inc.
InventorsKa-Kong Chan, George W. Holland, Perry Rosen
Life of this patent
Estimating the term…
Abstract
Eicosa-5,8-diynoic acids and 2-fluoro-eicostrien-5-ynoic acid and esters thereof which inhibit the synthesis of SRS-A are useful for treating and preventing asthma and allergic responses caused by SRS-A as well as useful in inhibiting inflammation.
Claims10
A compound of the formula ##STR30## wherein R is --COOR', R.sub.1 is hydrogen or fluoro;
- A and B are individually hydrogen or taken together form a carbon to carbon bond with a cis configuration:
- E and G are individually hydrogen or taken together form a carbon to carbon bond with a cis configuration with the proviso that at least one of A and B taken together or E and G taken together form a carbon to carbon bond with a cis configuration;
- and R' is hydrogen or lower alkyl;
- or pharmaceutically acceptable salts thereof.
1 more element
A compound of the formula ##STR31## wherein R is --COOR' and R', R.sub.2 and R.sub.3 are hydrogen;
- and .DELTA. designates a cis double bond.
Dependencies are inferred from the claim text.