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US 4,499,081 AGranted
Peptide compounds
AssigneeNyegaard & Co. A/S
InventorOle D. Laerum
Life of this patent
Estimating the term…
Abstract
The invention provides compounds of the general formula: ##STR1## (in which R.sup.1 is the residue of glycine or D-alanine, and all other amino-acid residues are in the L-form, X.sup.1 and X.sup.2, which may be the same or different, are OH or NH.sub.2 and n is 0 or 1) and their physiologically acceptable salts. The compounds of the invention are capable of inhibiting the myelopoietic system of humans and animals, thereby protecting said system against attack by cytotoxic drugs.
Claims7
A compound of the formula:
- ##STR5## (in which R.sup.1 is the residue of glycine or D-alanine, and all other amino-acid residues are in the L-form, X.sup.1 and X.sup.2, which may be the same or different, are OH or NH.sub.2 and n is 0 or 1) and their physiologically acceptable salts.
A compound which is L-pyroGlutamyl-L-glutaminyl-L-aspartyl-L-cysteinyl-L-lysine;
- L-pyroGlutamyl-L-glutamyl-L-aspartyl-L-cysteinyl-glycyl-L-lysine;
- L-pyroGlutamyl-L-glutamyl-L-aspartyl-L-cysteinyl-L-lysine;
- L-pyroGlutamyl-L-glutamyl-L-aspartyl-L-cysteinyl-D-alanyl-L-lysine;
- or
- L-pyroGlutamyl-L-glutamyl-L-aspartyl-L-cysteinyl-L-lysine amide.
2 more elements
A compound of the formula II:
- ##STR6## wherein R.sup.1 is the residue of glycine or D-alanine, and all other amino acid residues are in the L-form, R.sup.2 and R.sup.6 are amine protecting groups or hydrogen atoms, R.sup.3, R.sup.4 and R.sup.7 are NH.sub.2, protected amino or carboxyl protecting groups or OH, R.sup.5 is a thiol protecting group, and n is zero or one, and the physiologically acceptable salts thereof.
Dependencies are inferred from the claim text.