Arachidonic acid analogues as anti-inflammatory and anti-allergic agents
AssigneeSyntex (U.S.A.) Inc.
InventorPeter H. Nelson
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Abstract
Novel compounds of this invention are tetrazole, acylhydroxylamine, hydroxymethylketone and amide derivatives of unsaturated fatty acids which are selective inhibitors of the enzymes lipoxygenase and cyclooxygenase involved in the production of pain, inflammation, bronchoconstriction and allergic reactions. These compounds are beneficial in the treatment of a number of inflammatory and/or painful conditions and allergic reactions.
Claims60
A compound chosen from those represented by the formulas ##STR12## and their pharmaceutically acceptable, non-toxic salts wherein A is C.dbd.C or C.tbd.C;
- B is C.dbd.C or C.tbd.C;
- D is C--C, C.dbd.C, or C.tbd.C;
- E is C--C, C.dbd.C, or C.tbd.C;
- F is C--C, C.dbd.C, or C.tbd.C;
- Z is CH.sub.3, CH.sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 CH.sub.3 ;
- CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 ;
- and
- X is C(O)NHOH.
A compound chosen from those represented by the formulas ##STR13## and their pharmaceutically acceptable, non-toxic salts wherein A is C.dbd.C or C.tbd.C;
- B is C.dbd.C or C.tbd.C;
- D is C--C, C.dbd.C, or C.tbd.C;
- E is C--C, C.dbd.C, or C.tbd.C;
- F is C--C, C.dbd.C, or C.tbd.C;
- Z is CH.sub.3, CH.sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 CH.sub.3 ;
- CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 ;
- X is CONH.sub.2 and at least one of A, B, D, or F is C.tbd.C.
Dependencies are inferred from the claim text.