Plasminogen activator derivatives
OwnerKimihiro Shimizu, Tsuguji Nakahara +1inventors
InventorsKimihiro Shimizu, Tsuguji Nakahara, Taketoshi Kinoshita
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Abstract
A derivative of a human-originated non-immunogenic plasminogen activator is disclosed which comprises at least one polyalkylene glycol attached with at least one coupling agent to amino acid side chains of said plasminogen activator, said polyalkylene glycol having a molecular weight of 200-20,000 and optionally containing one or more alkyl and/or alkanoyl groups as substituents. Also disclosed are a process for producing such derivative and a thrombolytic agent containing such derivative.
Claims17
A derivative of a human-originated non-immunogenic plasminogen activator, comprising at least one polyalkylene glycol chemically bonded with at least one coupling agent to amino acid side chains of said plasminogen activator, wherein said polyalkylene glycol has a molecular weight in the range of 200-20,000 and is unsubstituted or is substituted with one or more alkyl or one or more alkanoyl groups.
Monomethyl ether polyethylene glycol-4,6-dichloro-1,3,5-triazine-modified urokinase, whose polyethylene glycol moiety has an average molecular weight of 5,000.
Polypropylene glycol-4-chloro-6-hydroxy-1,3,5-triazine-modified urokinase, whose polypropylene glycol moiety has an average molecular weight of 4,000.
A process for preparing a derivative of a human-originated non-immunogenic plasminogen activator, which comprises reacting a coupled product of at least one polyalkylene glycol and at least one coupling agent with a plasminogen activator, wherein said polyalkylene glycol has a molecular weight in the range of 200-20,000 and is unsubstituted or is substituted with one or more alkyl or one or more alkanoyl groups.
A derivative of a human-originated non-immunogenic plasminogen activator, produced by a process which comprises reacting a coupled product of at least one polyalkylene glycol and at least one coupling agent with a plasminogen activator, wherein said polyalkylene glycol has a molecular weight in the range of 200-20,000 and is unsubstituted or is substituted with one or more alkyl or one or more alkanoyl groups.
Dependencies are inferred from the claim text.