US 4,492,696 AGranted

Piperazine and homopiperazine compounds

AssigneeAdir

InventorsGilbert Reginier, Michel Laubie, Jacques Duhault

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Abstract

Piperazine and homopiperazine compounds of the formula: ##STR1## in which: A is a hydrocarbon radical from C.sub.3 to C.sub.5, in a straight or branched chain, which may contain one or two double bonds, and optionally substituted by one or more OH; B is CH or a nitrogen atom; m is 2 or 3; X--Y-- represents --CH.dbd.CH-- (CR'R").sub.n -- in which n is zero or 1, and R' and R" are hydrogen or methyl; Z is oxygen or sulfur, R is hydrogen, alkyl from C.sub.1 to C.sub.5, cycloalkyl from C.sub.3 to C.sub.7, or phenyl optionally substituted by fluorine, chlorine or alkyl from C.sub.1 to C.sub.5, and T is hydrogen, fluorine, chlorine or alkyl from C.sub.1 to C.sub.5. These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of all kinds of tissular hypoxy.

Claims4

Dependent claims

A compound selected from the group consisting of:

piperazine and homopiperazine compounds of the formula:
##STR16## in which:
A is selected from the group consisting of hydrocarbon radicals having from 3 to 5 carbon atoms inclusive, in straight and branched chain and these radicals containing one and two double bonds and substituted by one and two hydroxy;
m is an integer selected from 2 and 3;
--X--Y -- represents a group of the formula:
--CH.dbd.CH--(CR'R").sub.n -- in which n is selected from the group consisting of 0 and 1, and R' and R" which are the same or different are each selected from the group consisting of hydrogen and methyl;
Z is selected from the group consisting of oxygen and sulfur;
R is selected from the group consisting of hydrogen, alkyl having from 1 to 5 carbon atoms inclusive, cycloalkyl having from 3 to 7 carbon atoms inclusive, unsubstituted phenyl and phenyl mono- and poly-substituted by a substituent selected from the group consisting of fluorine, chlorine and alkyl having from 1 to 5 carbon atoms inclusive;
T is selected from the group consisting of hydrogen, fluorine, chlorine and alkyl having from 1 to 5 carbon atoms inclusive,
and the group ##STR17## is bonded to either one of the cycles forming the group:
##STR18## in the formula I;
and physiologically tolerable addition salts thereof.

9 more elements

Dependencies are inferred from the claim text.