Benzazepine derivatives, their pharmaceutical compositions and method of use

A compound of the formula ##STR50## wherein A is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --NH--CO, --CH.sub.2 CO-- or ##STR51## where R.sub.7 is alkyl of 1 to 3 carbon atoms, and B is methylene, carbonyl or thiocarbonyl;

• or
• A is --CO--CO--, --N.dbd.CH--, ##STR52## where R.sub.8 is hydrogen or alkyl of 1 to 3 carbon atoms substituted by a phenyl, methoxyphenyl or dimethoxyphenyl, and B is methylene;
• E is n-alkylene of 2 to 4 carbon atoms optionally substituted by an alkyl of 1 to 3 carbon atoms, 2-hydroxy-n-propylene, 2-hydroxy-n-butylene or 3-hydroxy-n-butylene;
• G is n-alkylene of 1 to 5 carbon atoms optionally substituted by an alkyl of 1 to 3 carbon atoms, wherein one methylene group of an n-alkylene of 2 to 5 carbon atoms can be replaced by a carbonyl group, with the proviso that B is methylene or carbonyl;
• or methylene-n-hydroxy-alkylene of 1 to 4 carbon atoms, where the methylene group is attached to the nitrogen atom;
• R.sub.1 is hydrogen, fluorine, chlorine, bromine, trifluoromethyl, amino, hydroxyl, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, phenyl(alkoxy of 1 to 3 carbon atoms), (alkyl of 1 to 3 carbon atoms)amino or di(alkyl of 1 to 3 carbon atoms)amino;
• R.sub.2 is hydrogen, fluorine, chlorine, bromine, hydroxyl, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms or phenyl(alkoxy of 1 to 3 carbon atoms);
• or
• R.sub.1 and R.sub.2, together with each other, are alkylene of 1 to 2 carbon atoms)dioxy;
• R.sub.3 is hydrogen, fluorine, chlorine, bromine, hydroxy, cyano, nitro, trifluoromethyl, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms;
• R.sub.4 is hydrogen, alkyl of 1 to 3 carbon atoms, hydroxy, alkoxy of 1 to 3 carbon atoms, amino, (alkyl of 1 to 3 carbon atoms)amino, di(alkyl of 1 to 3 carbon atoms)amino, (alkanoyl of 1 to 3 carbon atoms)amino, (alkoxy of 1 to 3 carbon atoms)carbonylamino, bis[(alkoxy of 1 to 3 carbon atoms)carbonyl]amino, (trifluoromethyl-methyl)amino or (trifluoromethyl-ethyl)-amino;
• or
• R.sub.3 and R.sub.4, together with each other, are (alkylene of 1 to 2 carbon atoms)dioxy;
• R.sub.5 is hydrogen, chlorine, bromine, cyano, hydroxy, alkyl or alkoxy, where each alkyl moiety may contain 1 to 4 carbon atoms;
• and
• R.sub.6 is hydrogen, alkyl of 1 to 3 carbon atoms, phenyl(alkyl of 1 to 3 carbon atoms), alkanoyl of 1 to 3 carbon atoms, (alkoxy of 1 to 3 carbon atoms)carbonyl or alkenyl of 3 to 5 carbon atoms;
• or a non-toxic, pharmacologically acceptable acid addition salt thereof.