Materials and method for preparing dialysis solutions containing bicarbonate ions

A method for preparing a bicarbonate dialysis solution, said dialysis solution consisting essentially of (a) about 120 to 155 m Eq per liter of sodium ion;

• (b) about 30 to 42 m Eq per liter of bicarbonate ion;
• (c) about 1 to 5 m Eq per liter of calcium ion;
• (d) about 0 to 2 m Eq per liter magnesium ion;
• (e) about 0 to 7 m Eq per liter of acetate ion;
• (f) about 0 to 3 m Eq per liter of potassium ion;
• (g) about 0 to 5 grams per liter dextrose;
• (h) about 80 to 115 m Eq per liter chloride ion;
• (i) about 0 to 5 m Eq per liter lactate ion;
• and (j) water to make one liter, said dialysis solution being prepared by admixing water and an acid concentrate consisting essentially of water, calcium chloride, magnesium chloride when required and an amount of acetic acid, hydrochloric or lactic acid effective for causing the dialysis solution to have a pH of 7.2 to 7.4, said acid concentrate being free of sodium chloride, with an aqueous solution consisting of sodium bicarbonate, sodium chloride, potassium chloride when required and dextrose when required and being free of calcium and magnesium salts;
• the aqueous bicarbonate comprising solution being prepared by admixing with water a substantially water-free particulate admixture consisting essentially of sodium chloride, sodium bicarbonate, potassium chloride when required and dextrose when required.

A method for preparing about 2 liters of a solution useful for peritoneal dialysis comprising:

• (a) packaging:
• (i) about 45.7 grams of a substantially water-free particulate admixture consisting essentially of 589 parts by weight of sodium bicarbonate, 823 parts by weight of sodium chloride and 2,700 parts by weight of dextrose in a flexible plastic bag;
• (ii) removing air from said flexible plastic bag, and (iii) sealing the resulting substantially air-free flexible plastic bag;
• (b) packaging about 1.666 ml of an acidic concentrated aqueous solution consisting essentially of 233 grams of calcium chloride per liter, 85 grams of magnesium chloride per liter and 378 grams of lactic acid per liter in a needle-equipped hypodermic syringe;
• (c) adding about 2 liters of de-aerated water to the substantially air-free flexible plastic bag without introducing air into the bag, and dissolving said water-free particulate admixture in said water;
• and (d) transferring the aforesaid acidic concentrated aqueous solution from the hypodermic syringe to the solution in said bag and mixing the resulting composition therein to form said solution useful for peritoneal dialysis.