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US 4,487,773 AGranted
1,2,4-Triazol-3-one antidepressants
AssigneeMead Johnson & Company
InventorsDavis L. Temple, Jr., Walter G. Lobeck, Jr.
Life of this patent
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Abstract
Phenoxyalkyl substituted-1,2,4-triazolones having anti-depressant properties typified by 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one are disclosed.
Claims29
A compound of Formula XI ##STR61## wherein n is 2-4;
- R.sub.2 is hydrogen or lower alkyl;
- X.sub.1 is oxygen or a direct bond;
- Y is hydrogen, halogen, lower alkoxy or CF.sub.3 with the proviso that when Y is hydrogen, n cannot be 2, R.sub.2 cannot be ethyl, X.sub.1 cannot be oxygen and Z cannot be phenyl having a mono halogen substituent;
- Z is benzyl or a radical selected from the group ##STR62## wherein R.sub.3 is hydrogen or halogen;
- R.sub.4 is halogen or CF.sub.3 ;
- R.sub.5 is hydrogen, halogen or cyano;
- R.sub.6 is hydrogen or halogen;
- or a pharmaceutically acceptable acid addition salt thereof.
5 more elements
5-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]- 4-ethyl-2,4-dihydro-2-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one.
5-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-2,4-dihydro -4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one.
5-[3-[4-(3-Chlorophenyl)-1-piperazinyl] propyl]-2-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one.
Dependencies are inferred from the claim text.