Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product
AssigneeTrustees of the University of Massachusetts
InventorDonald J. Hnatowich
Life of this patent
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Abstract
A dicyclic dianhydride rapidly and efficiently couples with a broad variety of amines such as polypeptides and proteins in non-aqueous or aqueous media and then may be chelated with a wide choice of radioisotope metallic cations to yield a radio-labeled product that is stable in vivo. A simple 1-step synthesis of the coupled amine in aqueous solution of neutral pH is described which requires only a few minutes time and with little accompanying hydrolysis.
Claims18
A chemical composition comprising:
- a primary or secondary amine comprising at least one amine group available for bonding as an amide bond;
- a radioactive metallic cation;
- and
- a chelating agent derived from a compound of the formula ##STR3## wherein R is a linking moiety containing between 1 and 25 carbon atoms, said chelating agent being bound to said amine group and to said metallic cation.
A process for making a radionuclide labeled composition comprising the steps of:
- preparing a solid chelating agent having the formula ##STR4## wherein R is a linking moiety containing between 1 and 25 carbon atoms;
- mixing said solid chelating agent with a primary or secondary amine containing at least one amine group able to form an amide bond with said chelating agent;
- and
- adding a radioactive metallic cation to said conjugate to form a transcomplexed molecule.
A chemical composition comprising:
- a primary or secondary amine comprising at least one amine group available for bonding as an amide bond;
- and
- a chelating agent derived from a compound of the formula ##STR5## wherein R is a linking moiety containing between 1 and 25 carbon atoms, said chelating agent being bound to said amine group and to said metallic cation.
A process for making a radionuclide composition capable of chelating metal comprising the steps of:
- preparing a solid chelating agent derived from a compound having the formula ##STR6## wherein R is a linking moiety containing between 1 and 25 carbon atoms;
- and
- mixing said solid chelating agent with a primary or secondary amine containing at least one amine group able to form an amide bond with said chelating agent.
Dependencies are inferred from the claim text.