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US 4,478,914 AGranted
Process for applying multiple layers of a protein and a ligand extender to a surface and to the multiple-layer system
OwnerRoger W. Gieseinventor
Life of this patent
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Abstract
A multiple-layer process for applying, in alternate, successive molecular layers, a protein material, and a ligand extender material to a surface to modify the properties of the surface and to the multiple-layer product so prepared.
Claims29
A process of modifying the surface properties of a material, which process comprises:
- applying alternate, molecular, successive layers of first and second materials to the surface to be modified, the first material comprising a ligand binding proteinaceous material and the second material comprising a reactive ligand extender material, one of the materials reacted to the surface and, thereafter, at least one additional layer of the first and second materials alternately secured and noncovalently ligand reacted to the underlying layer of the other material, to provide a modified surface, with the first or second material as the top surface layer.
A process of modifying the surface properties of a material, which process comprises:
- (a) applying alternate successive layers of a first or second material to the surface to be modified, the proteinaceous first material selected from the group consisting of lectins, protein A, avidin, avidin derivatives, streptavidin, antibodies and combinations thereof, and the ligand second extender material selected from the group consisting of simple sugars, biotin, biotin derivatives, biotin analogs, F.sub.c fragments of an immunoglobulin, hapten and combinations thereof to provide at least two noncovalent successive layers;
- (b) washing the surface between each applying step to remove unreacted first or second material;
- and
- (c) recovering a multiple layer material whose surface is modified.
1 more element
Dependencies are inferred from the claim text.