Secondary amines, their preparation and use in pharmaceutical compositions

A pharmaceutical composition useful for the treatment of obesity or hyperglycaemia in humans and animals which comprises an anti-obesity effective amount or an anti-hyperglycaemically effective amount of a compound of the formula (II):

• ##STR21## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is hydrogen, fluorine, chlorine, hydroxy, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino;
• R.sub.2 is hydrogen, fluorine, chlorine or hydroxyl;
• R.sub.3 is hydrogen, chlorine or methoxyl;
• R.sub.4 is carboxylic acid or a salt, ester or amide thereof;
• R.sub.5 is hydrogen, chlorine, fluorine, methyl, ethyl, methoxyl or hydroxyl or carboxylic acid or a salt, ester or amide thereof;
• R.sub.6 is hydrogen, methyl, or propyl;
• X is oxygen or a bond;
• R.sub.7 is hydrogen, methyl, ethyl or propyl and Y is alkylene of up to 6 carbon atoms or a bond, in combination with a pharmaceutically acceptable carrier.