Process for preparing alpha-fluorinated alkanediphosphonates
AssigneeUniv. of Southern California
InventorCharles E. McKenna
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Abstract
A method for the production of alpha-fluorinated methane diphosphonates consists of the reaction of diphosphonate esters with a strong base, preferably potassium t-butoxide, and perchloryl fluoride to produce alpha-mono and alpha,alpha-difluorinated derivatives which can be converted to the corresponding acids by mild hydrolysis. The synthesis of unsymmetrical alpha-fluorinated methanediphosphonate esters followed by selective hydrolysis produces unsymmetrical diesters of diphosphonic acids.
Claims4
A process for the preparation of .alpha.-fluorinated methanediphosphonates comprising reacting a methanediphosphonate ester having the formula
- [(RO.sub.2 P(O)]--CH.sub.2 --[P(O)(R.sub.x O).sub.2 ]
- with potassium tert-butoxide to form a methanediphosphonate carbanion, and reacting said carbanion with perchloryl fluoride, where R and R.sub.x are the same or dissimilar alkyl or aromatic radicals.
Dependencies are inferred from the claim text.