Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
AssigneeSyntex (U.S.A.) Inc.
InventorShabbir T. Anik
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Abstract
Disclosed herein are nasal spray compositions and methods for enhancing polypeptide absorption across nasal membranes comprising a chelating agent and a polypeptide in a pharmaceutically acceptable excipient.
Claims14
A nasal spray composition having enhanced polypeptide absorption which comprises 0.00005 to 10% weight/weight (w/w) of a pharmaceutically active polypeptide;
- 0.005 to 10% w/w of a pharmaceutically acceptable chelating agent;
- and a pharmaceutically acceptable excipient in a quantity sufficient to make weight.
A method for enhancing the absorption of pharmaceutically active polypeptides across nasal membranes which method comprises adding 0.005 to 10% weight/weight (w/w) of a pharmaceutically acceptable chelating agent to a nasal spray composition comprising 0.00005 to 10% w/w of a pharmaceutically active polypeptide and a pharmaceutically acceptable excipient in a quantity sufficient to make weight.
Dependencies are inferred from the claim text.