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US 4,469,632 AGranted
D-Arginine.sup.24 calcitonin
AssigneeArmour Pharmaceutical Company
InventorsRonald C. Orlowski, Jay K. Seyler
Life of this patent
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Abstract
New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a D-amino acid in position 24 instead of the natural L-amino acid. Also resin peptides are disclosed which may be converted to peptides having such biological activity, and processes for producing said resin peptides and said calcitonin peptides.
Claims4
Peptides having the structure:
- ##STR25##
Peptides having the structure:
- ##STR26## where R.sub.1 is S-n-alkyl, Cys or H and R.sub.2 is S-n-alkyl or H, R.sub.1 being S-n-alkyl, Cys or H when R.sub.2 is H and R.sub.2 being S-n-alkyl or H when R.sub.1 is H and H when R.sub.1 is S-n-alkyl or Cys.
D-Arg.sup.24 -calcitonin wherein the calcitonin is salmon calcitonin.
D-Arg.sup.24 -calcitonin wherein the calcitonin is eel calcitonin.
Dependencies are inferred from the claim text.