Esters of phosphinylalkanoyl substituted prolines
AssigneeE. R. Squibb & Sons, Inc.
InventorJohn Krapcho
Life of this patent
Estimating the term…
Abstract
Hypotensive activity is exhibited by compounds having the formula ##STR1## and salts thereof wherein R.sub.1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R.sub.2 is cycloalkyl, 3-cyclohexenyl or 2-alkyl-3-cyclohexenyl; R.sub.3 is alkyl, cycloalkyl, phenyl or alkoxy; R.sub.4 is hydrogen or alkyl; one of R.sub.5 and R.sub.6 is hydrogen and the other is alkyl-X-, phenyl-X-, alkoxy, phenyloxy, phenyl, cycloalkyl, alkyl, or phenylalkyl; or together R.sub.5 and R.sub.6 are --XCH.sub.2 CH.sub.2 X--; R.sub.7 is hydrogen or ##STR2## and n is 0 or 1.
Claims9
A compound having the formula ##STR55## or a salt thereof, wherein R.sub.1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl;
- R.sub.2 is cycloalkyl, 3-cyclohexenyl, or 2-alkyl-3-cyclohexenyl;
- R.sub.3 is alkyl, cycloalkyl, phenyl or alkoxy;
- R.sub.4 is hydrogen or alkyl;
- one of R.sub.5 and R.sub.6 is hydrogen and the other is alkyl-X-, phenyl-X-, alkoxy, phenyloxy, phenyl, cycloalkyl, alkyl, or phenylalkyl;
- or together R.sub.5 and R.sub.6 are --XCH.sub.2 CH.sub.2 X--;
- and X is --S--, ##STR56## R.sub.7 is hydrogen or ##STR57## and n is 0 or 1.
Dependencies are inferred from the claim text.