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US 4,468,396 AGranted
Antihypertensive benzothiadiazines
AssigneeSchering Corporation
InventorCharles V. Magatti
Life of this patent
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Abstract
This invention relates to benzothiadiazinyl-substituted carboxyalkyl dipeptides useful as combined antihypertensive and diuretic agents.
Claims22
A compound represented by the formula ##STR7## and the salts thereof, wherein W is ##STR8## X is halogen or CF.sub.3 ;
- Y is --CH.sub.2 --, --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 OCH.sub.2 --, or --CH.sub.2 SCH.sub.2 --;
- Z is sulfonyl or carbonyl;
- R.sub.1, R.sub.2, R.sub.4 and R.sub.5 are hydrogen or lower alkyl;
- R.sub.3 is hydrogen, lower alkyl, or amino lower alkyl;
- m is 0 to 5;
- and
- p is 0, 1 or 2 and q is 0, 1 or 2, provided that the sum of p and q is 1 or 2, and that in formula V p is not 0.
4 more elements
Dependencies are inferred from the claim text.