Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation

A compound having the structural formula ##STR72## and including all stereoisomers thereof;

• wherein Z is ##STR73## n is 1 or 2;
• R.sup.1 is H or lower alkyl;
• B is --CH.dbd.CH--, --C.tbd.C-- or (CH.sub.2).sub.2 ;
• Y is alkyl;
• aryl-lower alkyl;
• alkenyl;
• alkynyl;
• aryl, pyridyl, pyridyl-lower alkyl;
• substituted pyridyl wherein the substituent is 1 or 2 halogen or lower alkyl groups;
• thienyl;
• thienylalkyl;
• substituted thienyl wherein the substituent is 1 or 2 halogen or lower alkyl groups;
• cycloalkyl;
• substituted cycloalkyl wherein the substituent is 1 or 2 halogens, 1 or 2 lower alkyl groups or lower alkoxy groups;
• cycloalkylalkyl or substituted cycloalkylalkyl wherein the substituent is 1 or 2 halogens, 1 or 2 lower alkyl groups or lower alkoxy groups;
• y is 0 or 1,
• where y is 1, R.sup.3 is H or lower alkyl;
• R.sup.2 is lower alkyl, lower alkoxy, aryl, alkylamino, arylamino, aryloxy, pyridinyl or cycloalkyl or where y is 0 as indicated by ##STR74## R.sup.2 can be a --(CH.sub.2).sub.x linking group (wherein x is 3, 4 or 5) which together with ##STR75## may form an N-containing 5-, 6- or 7-membered heterocycle, with the proviso that when R.sup.3 is H, R.sup.2 is lower alkoxy;
• R.sup.4 is lower alkyl, cycloalkyl, aryl, aryl-alkyl or alkanoyl;
• p is 0 to 5;
• m is 1 to 8;
• and
• R.sup.5 is lower alkyl, lower alkoxy, aralkoxy or ##STR76## wherein R.sup.6 is lower alkyl or phenyl;
• wherein alkyl or lower alkyl by itself or part of another group contains 1 to 12 carbons, aryl by itself or part of another part refers to a monocyclic or bicyclic aromatic group which contains 6 to 10 carbon atoms in the ring and which ring may be unsubstituted or contain 1 or 2 halogen, lower alkyl and/or lower alkoxy groups, alkenyl contains 3 to 6 carbon atoms, alkynyl contains 3 to 6 carbon atoms, and cycloalkyl contains 3 to 6 carbon atoms, and cycloalkyl contains 3 to 12 carbon atoms in the ring.