Urea derivatives
AssigneeThe Procter & Gamble Company
InventorsBrian L. Buckwalter, Thomas R. LaHann
Life of this patent
Estimating the term…
Abstract
A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is O or S; wherein n=1 or 0; wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched; wherein R.sub.1 is OCH.sub.3, and wherein R.sub.2 is OH. These urea derivatives have analgesic and anti-irritant activity when administered to humans and lower animals.
Claims29
Compounds of formula:
- ##STR6## wherein n=1 or 0, wherein X is O or S when n=1, wherein X is S when n=0, wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched, wherein R.sub.1 is H, OH or OCH.sub.3 and R.sub.2 is H or OH when n=1, at least one of R.sub.1 and R.sub.2 being OH, and wherein R.sub.1 is OH or OCH.sub.3 and R.sub.2 is OH when n=0;
- and pharmaceutically acceptable salts therof.
A pharmaceutical composition in unit dosage form having analgesic activity which comprises a safe and effective amount of a compound of formula:
- ##STR7## wherein X is O or S, wherein n=1 or 0, wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched, wherein R.sub.1 is H, OH or OCH.sub.3 and R.sub.2 is H or OH when n=1, at least one of R.sub.1 and R.sub.2 being OH, and wherein R.sub.1 is OH or OCH.sub.3 and R.sub.2 is OH when n=0, or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable carrier.
A method for providing analgesia in humans and lower animals in need thereof, whihc comprises the step of administering to the human or lower animal a safe and effective amount of a compound of formula:
- ##STR8## wherein X is O or S, wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched, wherein R.sub.1 is H, OH or OCH.sub.3 and R.sub.2 is H or OH when n=1, at least one of R.sub.1 and R.sub.2 being OH, and wherein R.sub.1 is OH or OCH.sub.3 and R.sub.2 is OH when n=0;
- or a pharmaceutically acceptable salt thereof.
A depilatory composition having reduced dermal irritation, which comprises:
- (a) a depilatory amount of thioglycolate depilatory agent, and
- (b) a compound in an amount effective to prevent or reduce the dermal irritation of the thioglycolate depilatory agent and having the formula:
- ##STR9## wherein X is O or S, wherein n=1 or 0, wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched, wherein R.sub.1 is H, OH or OCH.sub.3 and R.sub.2 H or OH when n=1, at least one of R.sub.1 and R.sub.2 being OH or OCH.sub.3, and wherein R.sub.1 is OH or OCH.sub.3 and R.sub.2 is OH when n=0;
- and pharmaceutically acceptable salts thereof.
A method for preventing or reducing the dermal irritation caused by a thioglycolate depilatory agent, which comprises the step of applying to at least a portion of a depilated area a compound in an amount effective to prevent or reduce irritation caused by treatment of the depilated area with a thioglycolate depilatory agent, the compound having the formula:
- ##STR10## wherein X is O or S, wherein n=1 or 0, wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched, wherein R.sub.1 is H, OH, or OCH.sub.3 and R.sub.2 is H or OH when n=1, at least one of R.sub.1 and R.sub.2 being OH or OCH.sub.3, and wherein R.sub.1 is OH or OCH.sub.3 and R.sub.2 is OH when n=0;
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.