Thiazine and thiazepine containing compounds

A compound of the formula ##STR197## and pharmaceutically acceptable salts thereof wherein:

• ##STR198## R.sub.1 is hydrogen, lower alkyl, amino substituted lower alkyl, hydroxy substituted lower alkyl, or halo substituted lower alkyl;
• n is one or two;
• R.sub.5 and R.sub.6 are independently selected from the group consisting of hydrogen, lower alkyl, --(CH.sub.2).sub.m -cycloalkyl wherein said cycloalkyl is a saturated ring of 3 to 7 carbons, and ##STR199## m is zero or an integer from 1 to 4;
• R.sub.14 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, halo, trifluoromethyl, or hydroxy;
• p is an integer from 1 to 3 provided that p is more than one only if R.sub.14 is hydrogen, methyl, methoxy, chloro, or fluoro;
• R.sub.7 is alkyl of 1 to 10 carbons, ##STR200## --(CH.sub.2).sub.s -cycloalkyl wherein cycloalkyl is a saturated ring of 3 to 7 carbons, --(CH.sub.2).sub.t --NH.sub.2 ##STR201## s is zero or an integer from 1 to 7;
• t is an integer from 1 to 8;
• R.sub.9 and R.sub.12 are independently selected from the group consisting of lower alkyl, halo substituted lower alkyl-(CH.sub.2).sub.m -cycloalkyl wherein cycloalkyl is a saturated ring of 3 to 7 carbons, ##STR202## R.sub.8 and R.sub.2 are independently selected from the group consisting of hydrogen, lower alkyl, benzhydryl, an alkali metal ion, an alkaline earth metal ion, and ##STR203## R.sub.10 is hydrogen, lower alkyl, cycloalkyl wherein cycloalkyl is a saturated ring of 3 to 7 carbons or phenyl;
• and
• R.sub.11 is hydrogen, lower alkyl, lower alkoxy, cycloalkyl wherein cycloalkyl is a saturated ring of 3 to 7 carbons, phenyl, benzyl, or phenethyl.