Methods of stabilizing thimerosal in presence of polyvinylpyrrolidone
AssigneeAllergan Pharmaceuticals, Inc.
InventorsStanley W. Huth, Hali G. Wagner
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Abstract
A method of preparing solutions containing thimerosal and polyvinylpyrrolidone which results in improved stability of thimerosal is disclosed. The method involves applying a certain amount of heat to the polyvinylpyrrolidone while it is in aqueous solution and prior to its combination with thimerosal. The required thermal input to the polyvinylpyrrolidone solution is a function of four variables: solution temperature, heating time, external pressure and polyvinylpyrrolidone concentration. Advantageously this method may be employed in the manufacture of contact lens solutions.
Claims6
A process for manufacturing a solution containing the combination of polyvinylpyrrolidone and thimerosal which comprises heating an aqueous solution of polyvinylpyrrolidone to a temperature of about 85.degree. C. to about 121.degree. C., cooling said polyvinylpyrrolidone solution and adding an antibacterial or antifungal amount of thimerosal to said cooled polyvinylpyrrolidone.
Dependencies are inferred from the claim text.