Prostaglandins

A compound which is a bicyclo[2,2,1]hept-2Z-ene substituted at the 5-position by a group of the formula --R.sup.1 --COQ, where R.sup.1 is selected from the group consisting of C.sub.4 -C.sub.8 alkyl;

• --CH.sub.2 --CH.dbd.CH--(CH.sub.2).sub.m --, where m is an integer from 1 to 5;
• --CH.sub.2 --CH.sub.2 --CH.dbd.CH--(CH.sub.2).sub.n --, where n is an integer from 0 to 4;
• --X--(CH.sub.2).sub.p --, where p is an integer from 3 to 7;
• --CH.sub.2 --X--(CH.sub.2).sub.q --, where q is an integer from 2 to 6;
• --CH.sub.2 --CH.sub.2 --X--(CH.sub.2).sub.m --;
• and
• --CH.dbd.CH--(CH.sub.2).sub.3 --;
• wherein X is O or S;
• COQ is carboxy, a physiologically acceptable carboxylate salt, a branched or unbranched C.sub.1 -C.sub.5 alkyl ester or CONHSO.sub.2 CH.sub.3 ;
• and wherein said bicyclo[2,2,1]heptene is substituted at the 6-position by a grouping of the formula ##STR42## in which R.sub.4 is selected from the group consisting of unsubstituted C.sub.1 -C.sub.10 branched or unbranched aliphatic hydrocarbon residues and C.sub.1 -C.sub.10 branched or unbranched aliphatic hydrocarbon residues substituted by Ar, --OAr, or --SAr, where Ar is a phenyl or pyridyl residue which is unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, halogen substituted C.sub.1 -C.sub.5 branched or unbranched alkyl groups, sulphonamido groups, amino groups, hydroxy and C.sub.1 -C.sub.10 alkoxy groups;
• R.sub.2 represents hydrogen and R.sub.3 represents a hydroxy group, or R.sub.2 and R.sub.3 together represent the oxygen atom of a carbonyl group.