Synthetic analogues of .alpha.-melanotropin
AssigneeUniversity Patents, Inc.
InventorsVictor J. Hruby, Mac E. Hadley, Christopher B. Heward, Tomi K. Sawyer
Life of this patent
Estimating the term…
Abstract
Analogues of the tridecapeptide hormone, .alpha.-melanotropin (a-melanocyte stimulating hormone, .alpha.-MSH) of the formula: Ac-Ser.sup.1 -Tyr.sup.2 -Ser.sup.3 -Y.sup.4 -Glu.sup.5 -His.sup.6 -X.sup.7 -Arg.sup.8 -Trp.sup.9 -Gly.sup.10 -Lys.sup.11 -Pro.sup.12 -Val.sup.13 -NH.sub.2 wherein X and Y are amino acid residues and X is in a D-isomeric configuration. Preferred analogues, e.g. [Nle.sup.4, D-Phe.sup.7 ]-.alpha.-MSH, display increased in vitro and in vivo potency, prolongation and serum stability characteristics and may be covalently bonded to other elements or compounds (e.g., radioisotopes of iodine) without significant loss of biological activity.
Claims3
A tridecapeptide of the formula:
- Ac-Ser.sup.1 -Tyr.sup.2 -Ser.sup.3 -Y.sup.4 -Glu.sup.5 -His.sup.6 -X.sup.7 -Arg.sup.8 -Trp.sup.9 -Gly.sup.10 -Lys.sup.11 -Pro.sup.12 -Val.sup.13 -NH.sub.2
- X is D-phenylalinine Y is methionine or norleucine, and all remaining amino acid residues in said tridecapeptide are in L-isomeric configuration.
Dependencies are inferred from the claim text.