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US 4,456,613 AGranted
6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof
AssigneeE. I. Du Pont de Nemours and Company
InventorChia-Lin J. Wang
Life of this patent
Estimating the term…
Abstract
Biologically active 6-keto- and 6-hydroxy-8-azaprostanoids having the formula: ##STR1## wherein A is O or ##STR2## R is CO.sub.2 R.sup.4 or CH.sub.2 OH; R.sup.1 is H, CH.sub.3, or C.sub.2 H.sub.5 ; R.sup.2 is H, CH.sub.3, or F; R.sup.3 is CH.sub.3 or CF.sub.3 ; R.sup.4 is H, C.sub.1 to C.sub.12 n-alkyl, branched chain alkyl, or cycloalkyl, or a physiologically acceptable metal or amine salt cation; and n is an integer from 3 to 8.
Claims22
A compound of the formula:
- ##STR29## wherein A is .dbd.O or ##STR30## R is CO.sub.2 R.sup.4 or CH.sub.2 OH;
- R.sup.1 is H, CH.sub.3, or C.sub.2 H.sub.5 ;
- R.sup.2 is H, CH.sub.3, or F;
- R.sup.3 is CH.sub.3 or CF.sub.3 ;
- R.sup.4 is H, C.sub.1 to C.sub.12 n-alkyl, branched chain alkyl, or cycloalkyl, or a physiologically acceptable metal or amine salt cation;
- and
- n is an integer from 3 to 8.
4 more elements
Dependencies are inferred from the claim text.