Naphthyl or tetrahydronaphthyl-substituted naphthoic acid and derivatives
AssigneeSRI International
InventorsMarcia I. Dawson, Peter D. Hobbs, Krzysztof A. Derdzinski
Life of this patent
Estimating the term…
Abstract
Compounds of the formulas: ##STR1## where X is methyl, methoxy, chlorine, or hydrogen, Y and Y.sub.1 are fluorine or hydrogen, R is hydroxy, alkoxy with 0 or 1 hydroxy substituent, aroxy, or NR.sup.1 R.sup.2 where R.sup.1 is hydrogen, alkyl with 0 or 1 hydroxy substituent or aryl and R.sup.2 is alkyl with 0 or 1 hydroxy substituent or aryl with the proviso that when Y or Y.sup.1 is fluorine, the other Y or Y.sup.1 is hydrogen. These compounds are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.
Claims44
A compound of the formula:
- ##STR9## wherein ring A is a saturated ring and R.sub.1, R.sub.1 ', R.sub.4, and R.sub.4 ' are methyl and R.sub.2, R.sub.2 ', R.sub.3 and R.sub.3 ' are hydrogen or an aromatic ring and R.sub.3 =R.sub.3 '=methyl, R.sub.4 =R.sub.4 '=methyl, R.sub.2 =R.sub.2 '=methyl or hydrogen, and R.sub.1 =R.sub.1 '=methyl or hydrogen, and X is methyl, methoxy, chlorine or hydrogen, Y and Y.sub.1 are fluorine or hydrogen, R is hydroxy, alkoxy with 0 or 1 hydroxy substituent, aroxy, or NR.sup.1 R.sup.2 where R.sup.1 is hydrogen, alkyl with 0 or 1 hydroxy substituent or aryl and R.sup.2 is alkyl with 0 or 1 hydroxy or aryl with the provisos that when ring A is unsaturated and R.sub.1 =R.sub.1 '=hydrogen R.sub.2 =R.sub.2 '=hydrogen, when ring A is unsaturated and R.sub.2 =R.sub.2 '= hydrogen R.sub.1 =R.sub.1 '=hydrogen and that when Y or Y.sub.1 is fluorine the other Y or Y.sub.1 is hydrogen.
A compound of the formula:
- ##STR10## where R is hydroxy or ethoxy.
A compound of the formula ##STR11## where R is hydroxy or ethoxy.
A compound of the formula:
- ##STR12## where R is hydroxy or ethoxy.
A compound of the formula:
- ##STR13## where (a) X is hydrogen, methyl, methoxy or chlorine, Y is hydrogen, Y.sub.1 is fluorine, and R is ethoxy;
- or
- (b) X is hydrogen, methyl, methoxy or chlorine, Y is fluorine, Y.sub.1 is hydrogen and R is ethoxy;
- or
- (c) X is hydrogen, methyl, methoxy or chlorine, Y is hydrogen, Y.sub.1 is fluorine and R is hydroxy;
- or
- (d) X is hydrogen, methyl, methoxy or chlorine, Y is fluorine, Y.sub.1 is hydrogen, and R is hydroxy;
- or
- (e) X is methyl, methoxy or chlorine, Y is hydrogen, Y.sub.1 is hydrogen, and R is ethoxy;
- or
- (f) X is methyl, methoxy or chlorine, Y is hydrogen, Y.sub.1 is hydrogen and R is hydroxy.
Dependencies are inferred from the claim text.