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US 4,452,891 AGranted
Method for production of mycophenolic acid by fermentation
AssigneeAjinomoto Co., Inc.
InventorsTakao Kida, Takehiko Ishikawa, Hiroshiro Shibai
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Abstract
Mycophenolic acid is produced by aerobically culturing in a culture medium a mutant of the genus Penicillium capable of producing mycophenolic acid, said mutant being resistant to clofibrat, and recovering the mycophenolic acid which accumulates in the culture medium.
Claims1
A method for producing mycophenolic acid by fermentation, which comprises:
- (1) aerobically culturing in a culture medium under conditions suitable for the accumulation of said mycophenolic acid, a strain of Penicillium identified as Penicillium brevicompactum FERM BP-53, Penicillium brevicompactum FERM-BP-54, or Penicillium brevicompactum BP-55 which is capable of producing mycophenolic acid;
- and
- (2) recovering the mycophenolic acid which accumulates in the culture medium.
Dependencies are inferred from the claim text.