Isonitrile radionuclide complexes for labelling and imaging agents
AssigneesPresident and Fellows of Harvard College, Massachusetts Institute of Technology
InventorsAlun G. Jones, Alan Davison, Michael J. Abrams
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Abstract
A coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta, is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.
Claims36
A coordination complex of an isonitrile ligand and a radioactive metal selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb, and Ta.
An isonitrile complex having the formula:
- [A((CN).sub.x R).sub.y B.sub.z B'.sub.z' ].sup.n
- wherein A is a radionuclide selected from radioactive isotopes of Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Ta;
- (CN).sub.x R is a monodentate or polydentate isonitrile ligand bonded to the radionuclide through the carbon atom of the CN group;
- R is an organic radical;
- B and B' are independently other ligands selected from the class of solvents, halogen groups, and ligands comprising one or more neutral donor atoms capable of forming coordinant bonds with said radionuclide;
- x and y are each independently, integers from 1 to 8;
- z and z' are each independently 0 or an integer from 1 to 7;
- with the proviso that (xy)+z+z' is less than or equal to 8;
- and n indicates the charge of the complex and can be 0 (neutral), or a positive or negative integer.
An isontrile complex having the formula;
- [A(CNR).sub.6 ].sup.+
- wherein A is a radionuclide selected from technetium and .sup.188 Re, and R is an organic radical.
A cationic lipophilic hexakis t-butylisonitrile complex of technetium.
A kit for preparing a coordination complex of an isonitrile ligand and a radionuclide selected from the class consisting of radioactive isotope of Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta, said kit comprising a predetermined quantity of said isonitrile ligand and a predetermined quantity of a reducing agent capable of reducing a predetermined quantity of a preselected one of said radionuclides to form said complex.
A method for imaging body tissues comprising administering to an animal a radiopharmaceutical composition comprising a coordination complex of an isonitrile ligand and .sup.99m Tc, and detecting the localization of such complex in the body tissues by a gamma camera.
A method for detecting vascular emboli in an animal comprising administering to said animal a radiopharmaceutical composition comprising a coordination complex of an isonitrile ligand and .sup.99m Tc, and detecting the emboli by localization of said complex at said emboli with a gamma camera.
Dependencies are inferred from the claim text.