Radiohalogenation method
AssigneeResearch Corporation
InventorGeorge W. Kabalka
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Abstract
Organoborane compounds are halogenated by reacting an organoborane with iodinemonochloride, brominemono-chloride or a halide salt in the presence of a mild oxidizing agent.
Claims29
A method of radiohalogenating an organic compound, comprising:
- reacting a radiohalide salt with an organoborane compound derived from said organic compound in the presence of a mild oxidizing agent.
A method of halogenating an organic compound, comprising:
- reacting a halide salt with an organoborane compound derived from said organic compound in the presence of a mild oxidizing agent.
A method of radiohalogenating an organic compound, comprising:
- reacting radioiodinomonochloride or radiobrominemonochloride with an organoborane derived from said organic compound.
A method of halogenating an organic compound, comprising:
- reacting iodinemonochloride or brominemonochloride with an organoborane derived from said organic compound.
A radiopharmaceutical of the formula:
- ##STR50## wherein X* is iodine-125, or bromine-75 and R and R' independently are hydrogen, methyl or ethyl.
No-carrier-added radiotherapeutic compounds wherein the radionuclide of said radiotherapeutic compounds is selected from the group consisting of iodine-123 , iodine-125, bromine-75 and bromine-77.
No-carrier added radiodiagnostic compounds wherein the radionuclide is selected form the group consisting of iodine-123, iodine-125, bromine-77 and bromine-75.
A radiopharmaceutical of the formula:
- ##STR51## wherein X* is a radiohalogen atom and R is hydrogen or alkyl.
Dependencies are inferred from the claim text.