Tri-substituted imidazole derivatives, pharmaceutical preparations containing them, and their use

A compound of the formula I ##STR27## in which one of the radicals R.sub.1 and R.sub.2 represent pyrrolyl, furyl, thienyl, pyridyl, 1-oxidopyridyl or pyrimidyl each of which are unsubstituted or substituted by halogen, lower alkyl, hydroxy, lower alkoxy, and/or lower alkanoyloxy,

• and the other of the radicals R.sub.1 and R.sub.2 represents phenyl, pyrrolyl, furyl, thienyl, pyridyl, 1-oxidopyridyl or pyrimidyl each of which is unsubstituted or substituted by halogen, lower alkyl, hydroxy, lower alkoxy and/or lower alkanoyloxy;
• A represents lower alkylene, lower alkylidene, lower alkenylene, lower alkenylidene, cycloalkylene, cycloalkylidene or cycloalkyl-lower alkylidene;
• and
• R.sub.3 represents carboxy, carboxy esterified by a lower alkanol, by a 3- to 8-membered cycloalkanol, by phenol, by a hydroxypyridine or by a substituted phenol or substituted hydroxypyridine, or represents carbamoyl or carbamoyl mono-substituted by hydroxy, by amino, by phenyl or by substituted phenyl, or represents carbamoyl mono- or di-substituted by lower alkyl or carbamoyl di-substituted by 4- to 7-membered alkylene or 3-aza-, 3-lower alkyl-aza-, 3-oxa- or 3-thiaalkylene, wherein said lower alkanol and said cycloalkanol can be unsubstituted or substituted by hydroxy, mercapto, optionally substituted phenyl, lower alkoxy, phenyl-lower alkoxy optionally substituted in the phenyl moiety, lower alkylthio, phenyl-lower alkylthio optionally substituted in the phenyl moiety, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy-lower alkoxy optionally substituted in the phenyl moiety, carboxy-lower alkoxy, lower alkoxycarbonyl-lower alkoxy, or lower alkoxycarbonyl-lower alkoxy containing optionally substituted phenyl, or lower alkanoyloxy, and wherein substituted phenyl, phenol or hydroxypyridine can each be substituted by lower alkyl, lower alkoxy, halogen and/or trifluoromethyl, their isomers and salts thereof.