US 4,445,500 A · Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders

Abstract

A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischmeic and other diseased neurologic tissue during treatment are provided.

Claims6

Dependent claims

A method of treating hypoxic-ischemic central nervous system tissue comprising:

(a) providing a physiologically acceptable oxygenated fluorocarbon emulsion as treatment fluid;
(b) establishing a circulation of said fluid through an oxygenator at a first preselected flow rate to oxygenate said fluid;
(c) injecting said oxygenated fluid into the cerebrospinal pathway at a first injecting point and at a second preselected rate;
(d) substantially continuously withdrawing fluid from said cerebrospinal fluid pathway at a second point which is selected to create a circulation of said oxygented fluid in the vicinity of said hypoxic-ischemic tissue sufficient to support significant aerobic respiration of a portion of said tissue,
whereby said portion of said tissue will be metabolically sustained during said treatment.

2 more elements

Dependencies are inferred from the claim text.

Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders

Life of this patent

Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders

Life of this patent

Abstract

Claims6