Amides of acyl-carnitines, process for preparing same and pharmaceutical compositions containing such amides
OwnerClaudio Cavazzainventor
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Abstract
Novel amides of acyl-carnitines having general formula ##STR1## wherein R' is acetyl, propionyl, butyryl (unsubstituted or halogen-substituted) isobutyryl, .beta.-hydroxybutyryl, acetoacetyl, pantothenyl, and linoleyl, and R" is either an unsubstituted amino radical (provided that R' is ather than acetyl) or a substituted amino radical, are therapeutically effective in treatment of functional arrythmias or arrhythmias secondary to myocardialsclerotic diseases and as psychosti-mulants.
Claims7
An amide of an acyl-carnitine represented by the formula (I) ##STR16## wherein X.sup.- is a halogen anion;
- R is acetyl;
- halogen-substituted acetyl;
- propionyl;
- halogen-substituted propionyl;
- butyryl;
- halogen-substituted butyryl;
- isobutyryl;
- .beta.-hydroxy butyryl;
- acetoacetyl, linoleyl or pantothenyl;
- and R" is amino provided that R is not acetyl, propionyl or butyryl, or R" is 2-sulfonyl-ethylamino, (2-hydroxy-3-carbethoxy-propyl) amino, (1-carbomethoxy-2-methyl-propyl) amino, (1-carbomethoxy-3-methyl-n-butyl) amino, (1-carbomethoxy-2-methyl-n-butyl) amino, (1,2-dicarbomethoxy-ethyl) amino, (1,3-dicarbomethoxy-propyl) amino, (2-carbethoxy-benzyl) amino, (4-carbethoxy-phenyl) amino, 2-mercapto-1-carbomethoxy-ethyl) amino, 2-mercaptoethyl amino, (5-trimethyl ammomonium chloride-1-carbethoxy pentyl) amino, (carbethoxy methyl) amino or (carbethoxy ethyl) amino radical.
An amide of an acyl-carnitine represented by the formula (I) ##STR17## wherein X.sup.- is a halogen anion;
- R is halogen-substituted acetyl, halogen-substituted propionyl, halogen-substituted butyryl, linoleyl or pantothenyl;
- and R" is amino, 2-sulfonyl-ethylamino, (2-hydroxy-3-carbethoxy-propyl) amino, (1-carbomethoxy-2-methylpropyl) amino, (1-carbomethoxy-3-methyl-n-butyl) amino, (1-carbomethoxy-2-methyl-n-butyl) amino, (1,2-dicarbomethoxy-ethyl) amino, (1,3-dicarbomethoxy-propyl) amino, (2-carbethoxy-benzyl) amino, (4-carbethoxy-phenyl) amino, 2-mercapto-1-carbomethoxy-ethyl) amino, 2-mercaptoethyl amino, (5-trimethyl ammomonium chloride-1-carbethoxy pentyl) amino, (carbethoxy methyl) amino or (carbethoxy ethyl) amino radicals.
An amide of an acyl-carnitine represented by the formula (I) ##STR18## wherein X.sup.- is a halogen anion;
- R is acetyl;
- halogen-substituted acetyl;
- propionyl;
- halogen-substituted propionyl, butyryl;
- halogen-substituted butyryl;
- isobutyryl;
- .beta.-hydroxy butyryl;
- acetoacetyl, linoleyl or pantothenyl;
- and R" is 2-sulfonyl-ethylamino, (2-hydroxy-3-carbethoxy-propyl) amino, (1-carbomethoxy-2-methyl-propyl) amino, (1-carbomethoxy-3-methyl-n-butyl) amino, (1-carbomethoxy-2-methyl-n-butyl) amino, (1,2-dicarbomethoxy-ethyl) amino, (1,3-dicarbomethoxy-propyl) amino, (2-carbethoxy-benzyl) amino, (4-carbethoxy-phenyl) amino, 2-mercapto-1-carbomethoxy-ethyl) amino, 2-mercaptoethyl amino, (5-trimethyl ammomonium chloride-1-carbethoxy pentyl) amino, (carbethoxy methyl) amino or (carbethoxy ethyl) amino radicals.
Dependencies are inferred from the claim text.