Cyclopropyl analogs as estrogenic and anti-fertility agents

A method of treating a normal or pathological condition responsive to estrogenic activity in a female subject in need of such therapy comprising administering to the subject an estrogenically effective, non-toxic dosage of an agent having the generic structure:

• ##STR8## wherein:
• X is a halogen or hydrogen atom;
• R.sub.1 is a hydrogen atom, an alkyl group, containing from 1 to about 3 carbon atoms, a monocyclic group, a hydroxy substituted monocyclic group, or an alkoxy substituted monocyclic group in which the alkyl substitutent contains from 1 to about 3 carbon atoms;
• R.sub.2 is a hydrogen atom, a hydroxyl group, an alkoxy group in which the alkyl substituent contains from 1 to about 3 carbon atoms, a beta-dialkylaminoethoxy group wherein the alkyl substituent contains from 1 to about 3 carbon atoms, a beta-monoaminoheterocycloethoxy group, or pharmaceutically acceptable salts thereof;
• R.sub.3 is a hydrogen atom or an alkyl group containing from 1 to about 3 carbon atoms;
• and
• R.sub.4 is a hydrogen atom, a hydroxyl group, or an alkoxy group in which the alkyl substituent contains from 1 to about 3 carbon atoms.

The method of 12 wherein:

• X is a chlorine, fluorine, or bromine atom;
• R.sub.1 is a phenyl group, p-hydroxyphenyl group or p-methoxyphenyl group;
• R.sub.2 is a beta-dimethylaminoethoxy group, a beta-diethylaminoethoxy group, a beta-pyrrolidinoethoxy group, or pharmaceutically acceptable salts thereof;
• R.sub.3 is an ethyl group;
• and
• R.sub.4 is a hydrogen atom, a hydroxyl group, or a methoxy group.