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US 4,439,606 AGranted
Antiatherosclerotic 1-piperazinecarbonyl compounds
AssigneeAmerican Cyanamid Company
InventorsMila T. Du, Robert G. Shepherd
Life of this patent
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Abstract
This disclosure describes 4-aryl, -heteroaryl and -heteroarylmethyl-1-piperazinecarbonyl compounds which are capable of ameliorating atherosclerosis in mammals.
Claims30
A compound selected from those of the formula ##STR3## wherein A is selected from the group consisting of 2-pyrazinyl, 2-quinoxalinyl;
- B is selected from the group consisting of phenyl, mono- and polysubstituted phenyl (wherein the substituents may be fluoro, alkyl (C.sub.1 -C.sub.4), or trifluoromethyl), benzyl, mono- and disubstituted benzyl (wherein the substituents may be chloro, nitro or alkyl (C.sub.1 -C.sub.3) alkyl (C.sub.1 -C.sub.4), cycloalkyl (C.sub.3 -C.sub.6), pyridyl, 2-phenoxypropionyl, (alkyl (C.sub.1 -C.sub.4)amino,) polyfluoro(F.sub.7 -F.sub.14)-alkyl(C.sub.3 -C.sub.7), mono- and disubstituted phenylamino (wherein the substituents may be chloro, carboxylic acid or ethyl carboxylate), 6-p-chlorophenylhexyl, 5-(p-chlorobenzoyl)butyl, 2-p-chlorophenoxy-2-isopropyl and 1-methylbenzyl;
- and R is selected from the group comprising hydrogen and alkyl (C.sub.1 -C.sub.3).
The compound according to claim , 1-(o-methylphenylacetyl)-4-(2-pyrazinyl)piperazine.
Dependencies are inferred from the claim text.