Back to results
US 4,439,438 AGranted
Esters of acyl-carnitines, process for preparing same and pharmaceutical compositions containing such esters
OwnerClaudio Cavazzainventor
Life of this patent
Estimating the term…
Abstract
Novel esters of acyl-carnitines having general formula ##STR1## wherein R' is acetyl, propionyl, butyryl (unsubstituted or halogen-substituted), isobutyryl, .beta.-hydroxy butyryl, acetoacetyl, pantothenyl and linoleyl, and R" is an alkoxy radical either unsubstituted alkoxy, typically: isobutyloxy or substituted alkoxy, typically: trichloroethyloxy) are therapeutically effective in the treatment of myocardial hypocontractility and as antidepresants.
Claims5
Esters of acyl-carnitines represented by the general formula (I):
- ##STR28## X is halogen;
- R' is:
- acetyl;
- halogen-substituted acetyl isobutyryl;
- .beta.-hydroxy butyryl;
- acetoacetyl;
- pantothenyl and linoleyl;
- and
- R" is:
- methoxy, ethoxy, propyloxy, butyloxy, isopropyloxy, isobutyloxy, trichloroethyloxy, trifluoroethyloxy, 3-carbethoxy-2-propyloxy, 3-pyridyl-methoxy, 2-diethylaminoethoxy, 2-acetamido-3-methyl-butyroxy, 2-acetamido-4-methyl-penthyloxy, 2-acetamido-3-methyl-pentyloxy and 4-hydroxymethyl-5-hydroxy-6-methyl pyrid-3-yl methoxy radicals provided that when R" is methoxy, ethoxy, propyloxy or butyloxy then R' is not acetyl.
7 more elements
Dependencies are inferred from the claim text.