Prostaglandins

A compound which is a bicyclo(2,2,1)heptane or hept-2Z-ene which is substituted at the 5-position by a group of the formula --R.sup.1 --COQ, where R.sup.1 is selected from the group consisting of C.sub.4 -C.sub.8 alkyl;

• --CH.sub.2 --CH.dbd.CH--(CH.sub.2).sub.m --, wherein m is an integer from 1 to 5;
• --CH.sub.2 --CH.sub.2 --CH.dbd.CH(CH.sub.2).sub.n --, where n is an integer from 0 to 4;
• --X--(CH.sub.2).sub.p --, where p is an integer from 3 to 7;
• --CH.sub.2 --X--(CH.sub.2).sub.q --, where q is an integer from 2 to 6;
• --CH.sub.2 --CH.sub.2 --X--(CH.sub.2).sub.m --, and --CH.dbd.CH--(CH.sub.2).sub.3 --;
• wherein X is --O-- or --S--;
• COQ is COOH, a physiologically acceptable carboxylate salt, a branched or unbranched C.sub.1 -C.sub.5 alkyl ester or CONHSO.sub.2 CH.sub.3 ;
• and wherein said bicyclo(2,2,1)heptane or hept-2Z-ene is substituted at the 6-position by a grouping of the formula:
• --C(R).dbd.NNHCO--(NH).sub.a --R';
• wherein R is selected from the group consisting of hydrogen, unsubstituted C.sub.1 -C.sub.10 branched or unbranched aliphatic hydrocarbon residues, and C.sub.1 -C.sub.10 aliphatic hydrocarbon residues substituted by Ar, where Ar represents a monocyclic aromatic hydrocarbon or pyridyl residue, or such a residue substituted by one or more substituents selected from the group consisting of halogen, halogen substituted branched or unbranched C.sub.1 -C.sub.5 alkyl groups, sulphonamido groups, amino groups, hydroxy and C.sub.1 -C.sub.10 alkoxy;
• a is 0 or 1;
• and
• R' is selected from the group consisting of unsubstituted C.sub.1 -C.sub.10 branched or unbranched aliphatic hydrocarbon residues, Ar and C.sub.1 -C.sub.10 branched or unbranched aliphatic hydrocarbon residues substituted by --Ar, --OAr, or --SAr.