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US 4,438,100 AGranted
Sterilized preserved, stable mucine-containing solutions
AssigneeA/S Orthana Kemisk Fabrik
InventorsErik Balslev, Svenn S. Hansen, Ernst L. Pedersen
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AssigneeA/S Orthana Kemisk Fabrik
InventorsErik Balslev, Svenn S. Hansen, Ernst L. Pedersen
Estimating the term…
Sterilized, preserved, stable mucine-containing solutions for use for application to sensitive human mucous membranes of the oral cavity, the nasal system, and the eye ephithel contain an oxidizing bactericide, in particular hydrogen peroxide, as preservative. Even at very small hydrogen peroxide concentrations, solutions remain bactericidal over prolonged periods such as 1-2 years. Mucine used is porcine gastric mucine or bovine salivary mucine or--to adjust the polar/non-polar properties--a mixture of both. The pronounced lubricating effect, combined with suitable viscosity, low surface tension and ability to coat and protect mucous membranes renders the solutions well suited as artificial salivas, ophthalmic solutions, and carriers for medicaments.
An aqueous mucine-containing composition, in particular for application to human mucous membranes and/or for use as an ophthalmic solution, comprising a non-human mammalian mucine selected from the group consisting of buccal and gastrointestinal mucines, the composition having a viscosity of at the most 50 relative to water, as measured with an Oswald viscosimeter, said composition being sterilized and containing an oxidizing bactericide preservative which is present in a physiologically tolerable concentration with respect to the application of the composition.
A sterilized composition comprising a non-human mammalian mucine selected from the group consisting of buccal and gastrointestinal mucines and containing an oxidizing bactericide, as a preservative.
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