Oral composition containing dextranase and .alpha.-1,3 glucanase and a method for preventing and suppressing oral diseases using the same
AssigneeThe Research Foundation for Microbiai Diseases of Osaka University
InventorsKazuo Shimada, Masataka Akiyama, Masami Sudo
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Abstract
An oral composition which comprises a pharmaceutically acceptable carrier, dextranase and .alpha.-1,3 glucanase, said dextranase being present in an enzyme unit ratio of 1:2 to 2:1 relative to said .alpha.-1,3 glucanase. The oral composition according to the present invention exhibits a synergistic effect of dextranase and .alpha.-1,3 glucanase and is highly effective for not only preventing but also suppressing various oral diseases such as dental caries, gingivitis and alveolar pyorrhea.
Claims7
An oral composition synergistic at pH 6.5 which comprises a pharmaceutically acceptable carrier, dextranase and .alpha.-1,3 glucanase, said dextranase and said .alpha.-1,3 glucanase both being present in an amount of 0.5 to 100 enzyme units per gram of said oral composition, said dextranase being present in an enzyme unit ratio of 1:2 to 2:1 relative to said .alpha.-1,3 glucanase, said dextranase being one prepared from dextranase-biosynthesizing microorganisms belonging to the genus Corynebacterium, said .alpha.-1,3 glucanase being one prepared from an .alpha.-1,3 glucanase-biosynthesizing microorganism belonging to the genus Pseudomonas.
A method for preventing and suppressing smooth surface dental caries, fissure dental caries and gingivities induced by the formation of dental plaque formed through adhesion to the teeth and gingival of viscous glucans produced from sucrose by the action of caries causing streptococci, Streptococous mutans, given to the oral cavities of golden hamsters, which are said to be a model for smooth surface caries, and rats, which are said to be a model for fissure caries, which comprises administering to a patient an effective amount of an oral composition synergistic at pH 6.5 comprising a pharmaceutically acceptable carrier, dextranase and .alpha.-1,3 glucanase, said dextranase and said .alpha.-1,3 glucanase both being present in an amount of 0.5 to 100 enzyme units per gram of said oral composition, said dextranase being present in an enzyme-unit ratio of 1:2 to 2:1 relative to said .alpha.-1,3 glucanase, said dextranase being one prepared from dextranase-biosynthesizing microorganisms belonging to the genus Corynebacterium, said .alpha.-1,3 glucanase being one prepared from an .alpha.-1,3 glucanase biosynthesizing microorganism belonging to the genus Pseudomonas.
Dependencies are inferred from the claim text.