Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
AssigneePfizer Inc.
InventorEric C. Bigham
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Abstract
6'-Acylaminopenicillanoyloxymethyl esters of penicillanic acid 1,1-dioxide and useful as antibacterial agents. The 6'-aminopenicillanoyloxymethyl ester, halomethyl esters, alkylsulfonyloxymethyl esters and arylsulfonyloxymethyl esters of penicillanic acid 1,1-dioxide are all useful intermediates for the aforesaid antibacterial agents.
Claims3
A compound selected from the group consisting of 6'-(2-benzyloxycarbonylamino-2-phenylacetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide, 6'-(2-[4-nitrobenzyloxycarbonylamino]-2-phenylacetamido)penicillanoyloxyme thyl penicillanate 1,1-dioxide and 6'-(2-[4-nitrobenzyloxycarbonylamino]-2-[4-hydroxyphenyl]acetamido)penicil lanoyloxymethyl penicillanate 1,1-dioxide.
Dependencies are inferred from the claim text.