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US 4,430,337 AGranted
Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity
AssigneePfizer Inc.
InventorGerald F. Holland
Life of this patent
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Abstract
Hypoglycemic oxazolidine-2,4-diones, substituted at the 5-position with a (C.sub.5 -C.sub.9) unsaturated monocyclic, saturated bicyclic or unsaturated bicyclic hydrocarbon radical; methods for their preparation; and method for their use in the treatment of hyperglycemic mammals.
Claims23
A compound of the formula ##STR10## or a pharmaceutically-acceptable cationic salt thereof;
- wherein R.sup.1 is a hydrocarbon radical having a molecular formula which is either C.sub.n H.sub.2n-3 (having either two carbocyclic rings or one carbocyclic ring and one double bond) or C.sub.n H.sub.2n-5 (having two carbocyclic rings and one double bond), wherein n is an integer of value 5 to 9, which is further characterized by having within its structure:
- (a) at least one of said rings comprising five or more carbon atoms;
- and
- (b) up to one substituent (C.sub.1 -C.sub.3)alkyl or (C.sub.1 -C.sub.3) alkylidene group.
1 more element
Dependencies are inferred from the claim text.