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US 4,425,330 AGranted
Bovine mastitis vaccine and method for detecting efficacy thereof
AssigneeCornell Research Foundation, Inc.
InventorsNeil L. Norcross, Johanna P. Opdebeeck
Life of this patent
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Abstract
This invention relates to a vaccine for the prevention and/or control of gram-positive cocci, e.g. Str. agalactiae and S. aureus, induced bovine mastitis infections and to an immunological method, an enzyme linked immunosorbent assay (ELISA), for assaying the humoral immue response of the lactating bovine mammary gland to detect antibody variables associated with the vaccinated or suspected infected bovine.
Claims6
A vaccine effective for the prevention and/or control of gram-positive cocci caused bovine mastitis which comprises:
- an active ingredient component containing per dose:
- in total combination a bovine mastitis preventing or controlling amount of at least one of (a) or (b):
- (a) at least one S. aureus somatic antigen which is an encapsulated antigen derived from a bovine isolated inactivated S. aureus;
- or
- (b) a bovine mastitis preventing or controlling amount of at least one unencapsulated S. aureus antigen which is derived from a bovine isolated inactivated S. aureus;
- and
- (c) in total combination a bovine mastitis preventing and controlling amount of at least one of Str. agalactiae antigen derived from a bovine isolated inactivated Str. agalactiae;
- the antigen being derived from at least one of inactivated Str. agalactiae, Type I (Ia or Ib or Ic or mixtures), Type II and Type III;
- the amount of each of said Str. agalactiae antigen present being an amount sufficient to contribute at least about 17-280 mg N per dose;
- said active component being emulsified with sufficient mineral oil to provide enhanced vaccine response when administered to a bovine.
7 more elements
Dependencies are inferred from the claim text.