Hydroxyphenylacetamides having analgesic and anti-irritant activity
AssigneeThe Procter & Gamble Company
InventorsThomas R. LaHann, Brian L. Buckwalter
Life of this patent
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Abstract
A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein R is a linear or branched C.sub.3 -C.sub.11 alkyl, alkynyl or aralkyl group, a linear or branched C.sub.3 -C.sub.22 alkenyl group, or an unbranched or branched C.sub.6 -C.sub.11 cycloalkyl or cycloalkenyl group; and wherein one of R.sub.1 and R.sub.2 is OH, the other being OH or H. These hydroxyphenylacetamides have analgesic and/or anti-irritant activity when administered either topically or systemically.
Claims23
A compound, or pharmaceutically acceptable salt thereof, having the formula:
- ##STR8## wherein R is a linear or branched C.sub.8 -C.sub.10 alkyl group, a linear or branched C.sub.6 -C.sub.9 alkynyl or aralkyl group, a linear or branched C.sub.12 -C.sub.18 alkenyl group, or an unbranched or branched C.sub.6 -C.sub.11 cycloalkyl or cycloalkenyl group;
- and wherein one of R.sub.1 and R.sub.2 is OH, the other being OH or H.
A pharmaceutical composition in unit dosage form having analgesic activity, which comprises a safe and effective amount of a compound, or pharmaceutically acceptable salt thereof, having the formula:
- ##STR9## wherein R is a linear or branched C.sub.8 -C.sub.10 alkyl group, a linear or branched C.sub.6 -C.sub.9 alkynyl or aralkyl group, a linear or branched C.sub.12 -C.sub.18 alkenyl group, or an unbranched or branched C.sub.6 -C.sub.11 cycloalkyl or cycloalkenyl group;
- and wherein one of R.sub.1 and R.sub.2 is OH, the other being OH or H;
- and a pharmaceutically acceptable carrier.
A method for providing analgesia in humans and lower animals in need thereof which comprises the step of administering to the human or level animal a safe and effective amount of a compound, or pharmaceutically acceptable salt thereof, having the formula:
- ##STR10## wherein R is a linear or branched C.sub.3 -C.sub.11 alkyl, alkynyl or aralkyl group, a linear or branched C.sub.3 -C.sub.22 alkenyl group, or an unbranched or branched C.sub.6 -C.sub.11 cycloalkyl or cycloalkenyl group;
- and wherein one of R.sub.1 and R.sub.2 is OH, the other being OH or H.
Dependencies are inferred from the claim text.