Antiestrogenic and antiandrugenic benzothiophenes
AssigneeEli Lilly and Company
InventorCharles D. Jones
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Abstract
6-Hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thio phene, its ethers and esters, and the physiologically acceptable acid addition salts thereof, are valuable antiestrogens and antiendrogens.
Claims62
A compound of the formula ##STR5## a physiologically acceptable ester or ether thereof, or a physiologically acceptable acid addition salt thereof.
An antiestrogenic and antiandrogenic pharmaceutical composition comprising a pharmaceutically acceptable diluent and an effective amount of a compound of the formula ##STR7## a physiologically acceptable ester or ether thereof, or a physiologically acceptable acid addition salt thereof.
A method of alleviating a pathological condition of an endocrine target organ, which condition is dependent or partially dependent on an estrogen or on an androgen, which comprises administering to a subject suffering from such a condition an effective dose of a compound of the formula ##STR9## a physiologically acceptble ester or ether thereof, or a physiologically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.