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US 4,416,831 AGranted
Amino and substituted amino phosphinylalkanoyl compounds
AssigneeE. R. Squibb & Sons, Inc.
InventorEdward W. Petrillo, Jr.
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## wherein X is an imino acid or ester and R.sub.1 is hydrogen, ##STR2## are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
Claims12
A compound of the formula ##STR259## wherein R.sub.1 is ##STR260## n is zero or one;
- R.sub.5 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl, or phenethyl;
- R.sub.3 is hydrogen, lower alkyl, benzyl, or benzhydryl;
- R.sub.19 is hydrogen, lower alkyl, halo substituted lower alkyl, amino substituted lower alkyl, ##STR261## R.sub.20 is lower alkyl, phenyl, benzyl, or phenethyl;
- R.sub.2 is hydrogen, lower alkyl, lower alkenyl, halo substituted lower alkyl, ##STR262## R.sub.13 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, hydroxy, phenyl, phenoxy, phenylthio, or phenylmethyl;
- q is zero or an integer from 1 to 7;
- m is zero, one, two or three;
- and
- p is one, two or three provided that p is more than one only if R.sub.13 is hydrogen, methyl, methoxy, chloro, or fluoro.
5 more elements
Dependencies are inferred from the claim text.