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US 4,416,813 AGranted
Artificial carrier for immobilization of biological proteins
AssigneeFujizoki Pharmaceutical Co., Ltd.
InventorsMikio Ikeda, Takayuki Tomizawa
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Abstract
A novel artificial carrier is disclosed which is prepared from gelatin, a water-soluble polysaccharide, a sodium metaphosphate and an aldehyde. The carrier can be used to immobilize antibodies, antigens or enzymes. Immobilized antigens and antibodies can be used as a diagnostic reagent in assays involving antigen-antibody reactions.
Claims23
A process for producing an artificial carrier for immobilization of biological proteins which comprises:
- forming a solution of gelatin, a water soluble polysaccharide and sodium metaphosphate having the formula (NaPO.sub.3).sub.n, wherein n is a whole number from 3 to 6 at a temperature above the gelation temperature of said gelatin;
- mixing with agitation an acid with said solution to adjust the pH of said solution to between about 2.5 and 6 whereby particles are formed and treating said particles with an aldehyde to thereby insolubilize said particles.
Dependencies are inferred from the claim text.