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US 4,414,149 AGranted
Glycine.sup.8 -D-arginine.sup.24 calcitonin
AssigneeArmour Pharmaceutical Company
InventorsRonald C. Orlowski, Jay K. Seyler
Life of this patent
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Abstract
New peptides are disclosed which have biological activity of the same type as known calcitonins which have both a D-amino acid in position 24 instead of the natural L-amino acid and are substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
Claims4
Peptides having the structure:
- ##STR26##
Peptides having the structure:
- ##STR27## where R.sub.1 is S-n-alkyl, Cys or H and R.sub.2 is S-n-alkyl or H, R.sub.1 being S-n-alkyl, Cys or H when R.sub.2 is H and R.sub.2 being S-n-alkyl or H when R.sub.1 is H and H when R.sub.1 is S-n-alkyl or Cys.
Dependencies are inferred from the claim text.