Oxygen carrier
AssigneeAjinomoto Co., Inc.
InventorsYuji Iwashita, Katsumi Ajisaka, Keiji Iwasaki
Life of this patent
Estimating the term…
Abstract
An oxygen carrying material containing hemoglobin or a hemoglobin derivative covalently coupled through an amide bond to a polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, and copolymers of ethylene oxide and propylene oxide.
Claims12
An oxygen carrying material containing hemoglobin or a hemoglobin derivative covalently coupled through an amide bond to a polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, and copolymers of ethylene oxide and propylene oxide.
A method of preparing a hemoglobin-polymer complex for an oxygen carrier as a blood substitute by chemical reaction, in which the polymer is selected from the group consisting of polyethylene glycol, polypropylene glycol, and copolymers of ethylene oxide and propylene oxide, comprising:
- (1) introducing at least one carboxylic acid group to said polymer to give a carboxylic acid-containing polymer, and
- (2) coupling the carboxylic acid-containing polymer through an amide bond with an amino group of hemoglobin or a hemoglobin derivative.
Dependencies are inferred from the claim text.