Benzisothiazole and benzisoxazole piperazine derivatives
AssigneeMead Johnson & Company
InventorsDavis L. Temple, Jr., Joseph P. Yevich
Life of this patent
Estimating the term…
Abstract
Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is benzisothiazol-3-yl or benzisoxazol-3-yl and the other is alkylene attached to heterocycles such as azaspiro[4.5]decanedione, dialkylglutarimide, thiazolidinedione and spirocyclopentylthiazolidinedione or butyrophenone-like groups. The compounds have psychotropic properties and 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspior[4.5]deca ne-7,9-dione is a typical embodiment having selective antipsychotic activity.
Claims12
A compound of Formula (I) ##STR43## wherein R represents the radical ##STR44## wherein n is 3 or 4,
- R.sub.1 and R.sub.2 are independently lower alkyl of 1 to 4 carbon atoms,
- Y is oxygen or sulfur,
- Z is hydrogen or halogen
- or a pharmaceutically acceptable non-toxic acid addition salt thereof.
8-[4-[4-( 2,1-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dio ne.
Dependencies are inferred from the claim text.